Wir haben zuvor einen transgenen Mausstamm (LSL-TβRI CA ) erzeugt, der einen Cre-induzierbaren konstitutiv aktiven TGFβ-Typ-I-Rezeptor enthält ( Bartholin L. et al. 2008. Generation of mice with conditionally enabled transforming growth factor beta signaling through the TbetaRI/ALK5 Rezeptor, GENESIS). Die Transgenexpression hängt von der Exzision eines floxed-transcriptional STOP (LSL, Lox-STOP-Lox) ab, das sich stromaufwärts der TβRI CA befindetkodierende Sequenz. Um die korrekte […]
WeiterlesenSchlagwort: isotypes
Rainbow Linear Calibration Particles
The use of flow cytometry to analyze small particles has been practiced for several decades. More recently, due to the increased sensitivity of conventional and commercially available flow cytometers, along with the growing interest in other small particles, such as e.g. B. extracellular vesicles, increasingly used. Despite an increasing use of small particle flow cytometry, the […]
WeiterlesenExtended Synaptotagmin-1 (ESYT1) Antibody
Cystic fibrosis (CF) is the most common life-limiting (median age at death ~28 years) rare disease, affecting ~32,000 people in Europe (~85,000 worldwide). This inherited disorder results from mutations in the gene encoding the CF transmembrane conductance regulator (CFTR), an epithelial chloride (Cl – ) and bicarbonate (HCO 3 – ) anion channel. Despite symptomatic therapies, […]
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