Cystic fibrosis (CF) is the most common life-limiting (median age at death ~28 years) rare disease, affecting ~32,000 people in Europe (~85,000 worldwide). This inherited disorder results from mutations in the gene encoding the CF transmembrane conductance regulator (CFTR), an epithelial chloride (Cl – ) and bicarbonate (HCO 3 – ) anion channel. Despite symptomatic therapies, […]
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