Lentiviral DNA integration favors transcriptionally energetic chromatin. We beforehand confirmed that the interplay of human immunodeficiency virus sort 1 (HIV-1) capsid with cleavage and polyadenylation specificity issue 6 (CPSF6) localizes viral preintegration complexes (PICs) to nuclear speckles for integration into transcriptionally energetic speckle-associated domains (SPADs). Within the absence of the capsid-CPSF6 interplay, PICs uncharacteristically accumulate […]
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